The White-Footed mouse is a medium-sized, short-tailed, white-footed mouse. It is the most abundant rodent in mixed deciduous and coniferous forests in the eastern United States, and is probably equally abundant near farms. Adults are 90–100 millimetres (3.5–3.9 in) in length, not counting the tail, which can add another 63–97 millimetres (2.5–3.8 in). The mean life expectancy for the species is 45.5 months for females and 47.5 for males.

White-footed Mice are perfect swimmers, and so are able to colonise islands in lakes with relative ease. They are important ecologically because owls, weasels, snakes, and many other predators eat them.