The Battle of Misiche was a battle between the Sassanid Persians and the Romans somewhere in ancient Mesopotamia in the winter of 244 AD. It ended with a Sassanid victory.

The Romans were defeated and it is unclear whether Gordian died during battle or was assassinated later by his own officers.

Gordian's successor, Philip the Arab was proclaimed emperor of Rome and made peace with Shapur. Next major clash between the two empires took place in 252, when Shapur defeated the Romans at the Battle of Barbalissos and successfully invaded Syria and part of Anatolia.