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HMG box domain
DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB proteins, a number of sequence specific transcription factors, and other DNA-binding proteins. The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. The domain has the capacity to recognize and/or induce specific DNA structures and effect the accessibility of the DNA to other proteins involved in transcription, recombination, or DNA repair.
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- Part of Speech: noun
- Synonym(s): HMG-1-box_domain, HMG-box_domain, high_mobility_group_box_domains, HMG_1_box_domain
- Blossary:
- Industry/Domain: Medical; Health care
- Category: Medicine
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