Pestalotiopsis microspora is a species of endophytic fungus capable of breaking down and digesting polyurethane. The fungi is unique in that it degrades and utilises the common plastic polyurethane as a sole source of carbon when in anaerobic conditions.

Pestalotiopsis microspora was discovered by a group of Yale University students and professors in the Amazon rainforest. The finding may provide a solution to the world's mounting waste problems, as a large portion of waste is polyurethane-based. The findings were published in Applied and Environmental Microbiology journal.