ATP-(2'-5')oligo(A)adenylyltransferase

ATP-(2'-5')oligo(A)adenylyltransferase

An enzyme that catalyses the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. EC 2.7.7.-.

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