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Prion diseases
A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal prions. These diseases are characterised by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature ataxia dementia, and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional slow virus diseases.
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