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Ribozyme

An RNA molecule that owing to peculiarities in its folding, is able to catalyse the interchange of some of its phosphodiester linkages to achieve intramolecular splicing. Examples of ribozyme groups are hammerhead, hairpin and pseudo-knot RNAs, which are whimsically named for their topologies. Ribozymes normally cleave cis, i.e. intramolecularly, but can be engineered to cleave a designated RNA target trans, i.e. intermolecularly.

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