Superantigens

Superantigens

Superantigens are molecules that stimulate a subset of T cells by binding to MHC class II molecules and Vb domains of T-cell receptors, stimulating the activation of T cells expressing particular Vb gene segments. The staphylococcal enterotoxins are one of the sources of superantigens.

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Part of Speech: noun
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Industry/Domain: Biology
Category: Immunology
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Related terms

superantigen

Biology; Immunology

A molecule that activates all T cells with a particular Vβ gene seg ment, irrespective of their Vα expression.

superantigens

Biology; Immunology

Superantigens are molecules that stimulate a subset of T cells by binding to MHC class II molecules and Vb domains of T-cell receptors, stimulating the activation of T cells ...

superantigens

Agriculture; General agriculture

Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region.

superantigens

Medical; Health care; Medicine

Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with ...

superantigen

Biology; Microbiology

Superantigens are bacterial proteins that stimulate the immune system much more extensively than do normal antigens. They stimulate T cells to proliferate nonspecifically through ...

unresponsiveness

Biology; Immunology

Inability to respond to antigenic stimulus. Unresponsiveness may be specific for a particular antigen, or broadly nonspecific as a result of damage to the entire immune system, ...

V(D)J recombination

Biology; Immunology

Mechanism for generating antigen-specific receptors of T and B cells; it involves the joining of V, D, and J gene segments mediated by the enzyme complex V(D)J recombinase, and ...

vaccination

Biology; Immunology

Any protective immunization against a pathogen. Originally referred to immunization against smallpox with the less virulent cowpox (vaccinia) virus.

variable (V) regions

Biology; Immunology

The N-terminal portion of an Ig or TCR which contains the antigen-binding region of the molecule; V regions are formed by the recombination of V(D) and J gene segments.