The Battle of Paraitacene was a battle in the Second War of the Diadochi between Antigonus I Monophthalmus and Eumenes near Isfahan in 317 BC. The battle ended indecisive.

In the summer of 317 BC, Eumenes, trying to capitalise on an earlier victory, was on the move against Antigonus. The two armies came to face one another in the lands of the Paraetaceni, to the northeast of Susa.

In the center, the phalanxes engaged, again to Eumenes' advantage due to the incredible skill of the Argyraspides who, despite their age (60 to 70 years old), seemed invincible. With his light horse in ruins, and his phalanx being pushed back, the situation looked grave for Antigonus.

However, Antigonus observed that the very success of the Argyraspides had led them forward to reveal a gap in the battle line as it detached from their left flank. In a bold move Antigonus charged his heavy cavalry into this gap, wheeling to the rear of Eumenes' cavalry. The attack proved successful – ending what seemed to be the start of a Eumenes victory over another opponent. The battle slowed as both side tried to rally broken units. As the day ended, both armies retired to their camps. Antigonus claimed victory, even though he lost some 3,700 infantry to death, and a further 4,000 wounded. Eumenes came off with a loss of only 540 infantry killed and some 1,000 injured.