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DNA-dependent kinase
The genetic defect in scid mice, which cannot rearrange their T- or B-cell receptor genes and have a severe combined immunodeficiency phenotype, is in the enzyme DNA-dependent kinase. This enzyme is part of a complex of proteins that bind to the hairpin ends of double-stranded breaks in DNA, and its catalytic subunit is critical for VDJ recombination.
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- Category: Immunology
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