He was king of England from 1760 to 1820, it is during his reign that the American colonies were lost, it is a highly suspected that he suffered from a hereditary disease porphyria. They had to look for alternatives as the king had become irrational, his prime minister and the Queen ruled for some time and later his son. He was kept in isolation and it is highly believed that his becoming insane was caused by drugs given to him to succumb his alleged insanity.