
Home > Terms > English, UK (UE) > SMAC mimetic LCL161
SMAC mimetic LCL161
An orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signalling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation.
- Part of Speech: noun
- Synonym(s):
- Blossary:
- Industry/Domain: Pharmaceutical
- Category: Cancer drugs
- Company: NCI
- Product:
- Acronym-Abbreviation:
Other Languages:
Member comments
Terms in the News
Featured Terms
Cucumber
A long, green, cylinder-shaped member of the gourd family with edible seeds surrounded by mild, crisp flesh. Used for making pickles and usually eaten ...
Contributor
Featured blossaries
Browers Terms By Category
- Cardboard boxes(1)
- Wrapping paper(1)
Paper packaging(2) Terms
- Cooking(3691)
- Fish, poultry, & meat(288)
- Spices(36)
Culinary arts(4015) Terms
- Cosmetics(80)
Cosmetics & skin care(80) Terms
- Osteopathy(423)
- Acupuncture(18)
- Alternative psychotherapy(17)
- Ayurveda(9)
- Homeopathy(7)
- Naturopathy(3)
Alternative therapy(489) Terms
- Muscular(158)
- Brain(145)
- Human body(144)
- Developmental anatomy(72)
- Nervous system(57)
- Arteries(53)