
Home > Terms > English, UK (UE) > SMAC mimetic LCL161
SMAC mimetic LCL161
An orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signalling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation.
- Part of Speech: noun
- Synonym(s):
- Blossary:
- Industry/Domain: Pharmaceutical
- Category: Cancer drugs
- Company: NCI
- Product:
- Acronym-Abbreviation:
Other Languages:
Member comments
Terms in the News
Featured Terms
Michael Jackson
Dubbed the Kind of Pop, Michael Joseph Jackson (August 29, 1958 – June 25, 2009) was a celebrated American music artist, dancer, and ...
Contributor
Featured blossaries
Browers Terms By Category
- Radiology equipment(1356)
- OBGYN equipment(397)
- Cardiac supplies(297)
- Clinical trials(199)
- Ultrasonic & optical equipment(61)
- Physical therapy equipment(42)
Medical devices(2427) Terms
- Wine bottles(1)
- Soft drink bottles(1)
- Beer bottles(1)
Glass packaging(3) Terms
- Cultural anthropology(1621)
- Physical anthropology(599)
- Mythology(231)
- Applied anthropology(11)
- Archaeology(6)
- Ethnology(2)
Anthropology(2472) Terms
- Osteopathy(423)
- Acupuncture(18)
- Alternative psychotherapy(17)
- Ayurveda(9)
- Homeopathy(7)
- Naturopathy(3)
Alternative therapy(489) Terms
- Advertising(244)
- Event(2)