Home > Terms > English, UK (UE) > SMAC mimetic LCL161

SMAC mimetic LCL161

An orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signalling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation.

This is auto-generated content. You can help to improve it.
0
Collect to Blossary

Member comments

You have to log in to post to discussions.

Terms in the News

Featured Terms

Harry8L
  • 0

    Terms

  • 0

    Blossaries

  • 1

    Followers

Industry/Domain: Computer Category: Storage

DNA hard drive

A digital storage device that is capable of storing huge amounts of data using the same method evolved by nature to write and read computer data. The ...

Contributor

Featured blossaries

Catholic Devotions

Category: Religion   1 18 Terms

The Asian Banker Awards Program

Category: Business   1 5 Terms

Browers Terms By Category