The Siege of Gaza was a siege ordered by Alexander the Great of the city Gaza controlled by Persian Empire in October 332 BC.

Batis, the commander of the fortress of Gaza, refused to surrender to Alexander. When Gaza was taken, the male population was put to the sword and the women and children were sold into slavery. As a result of the Siege, Alexander was allowed to proceed south in to Egypt securely, without his line of communications being threatened from the North by Batis from Gaza.