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Caspase
The caspases are a family of proteases responsible for carrying out the cell death process. In a living cell, these proteases are kept inactive by proteins on the mitochondrial cell surface from the BcL-2 family. When a cell is exposed to cell death signals such as ischemia, chemotherapy or radiation, BcL-2 function is blocked and caspase activators initiate the cell death cascade.
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- Part of Speech: noun
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- Industry/Domain: Health care
- Category: Genetic disorders
- Company: National Library of Medicine
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