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Chromatin remodelling

1) Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.

2) Chromatin remodelling involves alterations of the content or activity of DNA-binding and chromatin-associated proteins that affect the function and higher order conformational state of chromatin, as well as the activity of specific genes or functional DNA regions.

3) The mechanisms involved with making the DNA in CHROMATIN more or less accessible to transcription machinery.

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