Endogenous pyrogens

Endogenous pyrogens

Cytokines (e.g. IL-1, TNF-α) that can induce a rise in body temperature. They are distinct form exogenous substances such as endotoxin from gram-negative bacteria that induce fever by triggering endogenous pyrogen synthesis.

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Industry/Domain: Biology
Category: Immunology
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Related terms

endogenous pyrogens

Biology; Immunology

Cytokines (e.g. IL-1, TNF-α) that can induce a rise in body temperature. They are distinct form exogenous substances such as endotoxin from gram-negative bacteria that induce ...

endogenous pyrogen

Biology; Microbiology

A substance such as the lymphokine interleukin-1, which is produced by host cells and induces a fever response in the host. It also is called simply a pyrogen.

pyrogens

Medical; Health care; Medicine

Substances capable of increasing body temperature and cause fever and may be used for fever therapy. They may be of microbial origin, often polysaccharides, and may contaminate ...

unresponsiveness

Biology; Immunology

Inability to respond to antigenic stimulus. Unresponsiveness may be specific for a particular antigen, or broadly nonspecific as a result of damage to the entire immune system, ...

V(D)J recombination

Biology; Immunology

Mechanism for generating antigen-specific receptors of T and B cells; it involves the joining of V, D, and J gene segments mediated by the enzyme complex V(D)J recombinase, and ...

vaccination

Biology; Immunology

Any protective immunization against a pathogen. Originally referred to immunization against smallpox with the less virulent cowpox (vaccinia) virus.

variable (V) regions

Biology; Immunology

The N-terminal portion of an Ig or TCR which contains the antigen-binding region of the molecule; V regions are formed by the recombination of V(D) and J gene segments.