Home > Terms > English, UK (UE) > Frameshift mutation

Frameshift mutation

1) An insertion or deletion involving a number of base pairs that is not a multiple of three and consequently disrupts the triplet reading frame, usually leading to the creation of a premature termination (stop) codon and resulting in a truncated protein product

2) A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three. "Divisible by three" is important because the cell reads a gene in groups of three bases. Each group of three bases corresponds to one of 20 different amino acids used to build a protein. If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly.

This is auto-generated content. You can help to improve it.
0
Improve it
More
Collect to Blossary

Other Languages:

More

Member comments

You have to log in to post to discussions.

Related terms

frameshift mutation
Biotechnology; Genetic engineering

A mutation that changes the reading frame of an mRNA, either by inserting or deleting nucleotides.

frameshift mutation
Medical; Human genome

1) An insertion or deletion involving a number of base pairs that is not a multiple of three and consequently disrupts the triplet reading frame, usually leading to the creation ...

frameshift mutation
Archaeology; Human evolution

A mutational addition or deletion of a base pair in a gene that disrupts the normal reading frame ofan mRNA, which is read in groups of three bases.

frameshift mutation
Agriculture; General agriculture

A type of mutation in which a number of nucleotides not divisible by three is deleted from or inserted into a coding sequence, thereby causing an alteration in the reading frame ...

frameshift mutation
Medical; Health care; Medicine

A type of mutation in which a number of nucleotides deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the reading ...

frameshift mutation
Biology; Biochemistry; Molecular biology

The insertion or deletion of a nucleotide pair or pairs, causing a disruption of the translational reading frame.

eugenics
Biology; Human genome

Eugenics is a bio-social movement which advocates the practice that very talented people should spread their genes by having more children, and less talented people should be ...

celiac disease
Medical; Human genome

A digestive disease that is caused by an immune response to a protein called gluten, which is found in wheat, rye, barley, and oats. Celiac disease damages the lining of the ...

atherosclerosis
Medical; Human genome

1) Age, lifestyle, diet, and gene related degeneration of arteries due to deposition of lipoid plaques (atheromas) on inner arterial walls; main cause of coronary artery disease, ...

astigmatism
Medical; Human genome

1) Unequal curvature of the refractive surfaces of the eye. Thus a point source of light cannot be brought to a point focus on the retina but is spread over a more or less ...

bone marrow transplantation
Medical; Human genome

The transference of bone marrow from one human or animal to another.

cavernous
Medical; Human genome

1) Having caverns or cavities. 2) Of tissue: composed largely of vascular sinuses and capable of dilating with blood to bring about the erection of a body part.

Terms in the News

Featured Terms

Harry8L
  • 0

    Terms

  • 0

    Blossaries

  • 1

    Followers

Industry/Domain: Festivals Category: Christmas

Candle

A light source typified by a wick embedded in solid fuel, usually wax or fat, and used in Christianity to symbolise the Light of Jesus Christ.

Contributor

Featured blossaries

Kitchen cabinets online

Category: Other   1 3 Terms

Bang & Olufsen

Category: Technology   2 4 Terms

Browers Terms By Category

TERMS

SOCIAL

EXTRAS

SOLUTIONS