
Home > Terms > English, UK (UE) > Frameshift mutation
Frameshift mutation
1) An insertion or deletion involving a number of base pairs that is not a multiple of three and consequently disrupts the triplet reading frame, usually leading to the creation of a premature termination (stop) codon and resulting in a truncated protein product
2) A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three. "Divisible by three" is important because the cell reads a gene in groups of three bases. Each group of three bases corresponds to one of 20 different amino acids used to build a protein. If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly.
- Part of Speech: noun
- Synonym(s):
- Blossary:
- Industry/Domain: Medical
- Category: Human genome
- Company: National Library of Medicine
- Product:
- Acronym-Abbreviation:
Other Languages:
Member comments
Terms in the News
Featured Terms
Superbus
A 15ft-long, six-wheeled, Aerodynamic and luxurious vehicle, the Superbus can carry 23 passengers and reach speeds of up to 155mph (255kph), although ...
Contributor
Featured blossaries
Browers Terms By Category
- Lingerie(48)
- Underwear(32)
- Skirts & dresses(30)
- Coats & jackets(25)
- Trousers & shorts(22)
- Shirts(17)
Apparel(222) Terms
- Cables & wires(2)
- Fiber optic equipment(1)
Telecom equipment(3) Terms
- Material physics(1710)
- Metallurgy(891)
- Corrosion engineering(646)
- Magnetics(82)
- Impact testing(1)
Materials science(3330) Terms
- Health insurance(1657)
- Medicare & Medicaid(969)
- Life insurance(359)
- General insurance(50)
- Commercial insurance(4)
- Travel insurance(1)
Insurance(3040) Terms
- Legal documentation(5)
- Technical publications(1)
- Marketing documentation(1)