Home > Terms > English, UK (UE) > Gene dosage PCR (gd-PCR)
Gene dosage PCR (gd-PCR)
A method for quantification of the relative amount of a gene in a biological sample. One primer is constructed to hybridise with a gene known to be in the chromosome in question (e.g. chromosome 21 in the case of Down's syndrome) and another to hybridise to an unrelated gene in a different chromosome. Quantification of the amplified PCR products is sufficiently precise to distinguish a 50% increase in the chromosome 21 gene.
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