Hybridomas

Hybridomas

Monoclonal antibodies are most commonly produced from hybridomas. These are hybrid cell lines formed by fusing a specific antibody-producing B lymphocyte with a myeloma cell that is selected for its ability to grow in tissue culture and for an absence of immunoglobulin chain synthesis.

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Industry/Domain: Biology
Category: Immunology
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hybridoma

Biology; Immunology

An immortalized hybrid cell resulting from the in vitro fusion of an antibody-secreting B cell with a myeloma; it secretes antibody without stimulation and proliferates ...

hybridomas

Biology; Immunology

Monoclonal antibodies are most commonly produced from hybridomas. These are hybrid cell lines formed by fusing a specific antibody-producing B lymphocyte with a myeloma cell that ...

hybridoma

Biotechnology; Genetic engineering

A hybrid cell, derived from a B (antibody producing) lymphocyte fused to a tumour cell, which grows indefinitely in tissue culture and is selected for the secretion of the ...

hybridoma

Plants; Plant pathology

A cell produced by the fusion of an antibody-producing cell and a lymphoma (cancer) cell for production of monoclonal antibodies.

hybridoma

Medical; Health care; Medicine

Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure monoclonal antibodies or T-cell ...

hybridoma

Biology; Biochemistry; Molecular biology

A cell that is useful in production of quantities of a monoclonal antibody; a fusion of a myeloma cell and a spleen lymphocyte that, like the myeloma cell, can divide in culture ...

unresponsiveness

Biology; Immunology

Inability to respond to antigenic stimulus. Unresponsiveness may be specific for a particular antigen, or broadly nonspecific as a result of damage to the entire immune system, ...

V(D)J recombination

Biology; Immunology

Mechanism for generating antigen-specific receptors of T and B cells; it involves the joining of V, D, and J gene segments mediated by the enzyme complex V(D)J recombinase, and ...

vaccination

Biology; Immunology

Any protective immunization against a pathogen. Originally referred to immunization against smallpox with the less virulent cowpox (vaccinia) virus.

variable (V) regions

Biology; Immunology

The N-terminal portion of an Ig or TCR which contains the antigen-binding region of the molecule; V regions are formed by the recombination of V(D) and J gene segments.