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Hydroxylamine and osmium tetroxide (HOT) technique (chemical mismatch detection)
A method for detection of single base substitutions in DNA fragments. Heteroduplexes of normal DNA and homologous mutant DNA are generated; the presence of C mismatches allows cleavage with hydroxylamine and the presence of C and T mismatches allows cleavage with osmium tetroxide. Cleavages are detected after polyacrylamide-gel electrophoresis.
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- Category: Biochemistry; Molecular biology
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