Home > Terms > English, UK (UE) > Nucleotide excision repair (NER)
Nucleotide excision repair (NER)
1) In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognises a wide range of substrates, including damage caused by UV irradiation and chemicals.
2) Nucleotide Excision Repair (NER) mends DNA regions that contain chemical adducts, such as UV-induced thymine dimers or carcinogenic adducts, which distort the DNA helix and interfere with replication and transcription. NER is targeted to actively transcribed regions of the genome. During NER in eukaryotes, shape irregularities are detected by protein complexes that slide along the DNA molecule and induce cuts on each side of a lesion several nucleotides away. Removal of the damaged 25-30 nucleotide fragment is followed by repair synthesis and ligation.
- Part of Speech: noun
- Synonym(s):
- Blossary:
- Industry/Domain: Health care
- Category: Genetic disorders
- Company: National Library of Medicine
- Product:
- Acronym-Abbreviation:
Other Languages:
Member comments
Terms in the News
Featured Terms
My Glossary
My Glossary enables freelance translators, technical writers, and content managers to store, translate, and share personal glossaries on ...
Contributor
Featured blossaries
Browers Terms By Category
- Hand tools(59)
- Garden tools(45)
- General tools(10)
- Construction tools(2)
- Paint brush(1)
Tools(117) Terms
- SAT vocabulary(5103)
- Colleges & universities(425)
- Teaching(386)
- General education(351)
- Higher education(285)
- Knowledge(126)
Education(6837) Terms
- SSL certificates(48)
- Wireless telecommunications(3)
Wireless technologies(51) Terms
- Software engineering(1411)
- Productivity software(925)
- Unicode standard(481)
- Workstations(445)
- Computer hardware(191)
- Desktop PC(183)