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Peplomycin
A semisynthetic analogue of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity.
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- Part of Speech: noun
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- Industry/Domain: Pharmaceutical
- Category: Cancer drugs
- Company: NCI
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