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Reduced-intensity stem cell transplantation

A form of allogeneic transplantation, now in clinical trials. In a reduced intensity transplant, patients receive lower doses of chemotherapy drugs and/or radiation in preparation for the transplant. Immunosuppressive drugs are used to prevent rejection of the graft, and the engraftment of donor immune cells may allow these cells to attack the disease (graft-versus-lymphoma effect). Studies to determine the usefulness of reduced-intensity stem cell transplantation in older patients are also under way.

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