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Scaffold protein
One of the non-enzymic components of a multi- protein signal transduction complex. The complex is assembled upon activation of the receptor or is assembled but dormant until receptor activation. The scaffold is the framework for assembly at the cytoplasmic domain of a receptor; with the assistance of anchoring proteins it recruits kinases, phosphatases and other enzymes, and, with the assistance of adaptor proteins, other factors which will continue the signal sequence within the cell.
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- Part of Speech: noun
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- Category: Biochemistry; Molecular biology
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