Home > Terms > English, UK (UE) > Structure-activity relationships by nuclear magnetic resonance (SAR by NMR)
Structure-activity relationships by nuclear magnetic resonance (SAR by NMR)
An approach to drug discovery. Pairs of low affinity molecules, each having an affinity constant in the micromolar range and binding to discrete areas of a biomolecule, as determined by NMR, are combined in various ways to happen upon a hybrid molecule that allows both ligands to attach and has a binding constant in the nanomolar range.
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