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Triplex-forming oligonucleotide (TFO)
An oligonucleotide that recognises a specific dsDNA sequence. Designed to affect the expression of a specific gene, it lies in the major groove of the double helix and forms Hoogstein base pairs with the purine-rich strand.
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- Part of Speech: noun
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- Industry/Domain: Biology
- Category: Biochemistry; Molecular biology
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