Biochemistry

Biochemistry

The scientific study of the chemistry of living matter.

Industry: Biology; Biotechnology

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Biochemistry

Death-associated protein (DAP)

Biology; Biochemistry

A protein that induces apoptosis. It binds to a death receptor on the plasma membrane, resulting in an intracellular cascade of events that acitivates caspases and eventually causes apoptosis.

Side shelf experiment

Biology; Biochemistry

An experimental approach to discovery of a metabolic precursor or regulator, in which candidates for activity are randomly selected according to availability rather than by intelligent design.

Normalised cDNA library

Biology; Biochemistry

A library that includes all cDNA clones at approximately equal frequencies, unlike most cDNA libraries, which represent cDNAs in rough proportion to the occurrence of their mRNA in the source.

Simple sequence DNA

Biology; Biochemistry

The highly repetitive non-coding DNA of a satellite that serves a structural role in mitosis; used for genetic characterization by its polymorphism (simple sequence length polymorphism, SSLP).

Molecular modelling

Biology; Biochemistry

Any of the computational approaches for relating chemical or physical properties to structure, e.g. design of agonists or antagonists from the X-ray crystallography data of a receptor protein.

Synzyme

Biology; Biochemistry

A synthetic enzyme, e.g. a polymer with an inert backbone, upon which dissociating groups like amines and carboxyls are mounted in a random fashion; or a protein product of in vitro evolution.

Excimer

Biology; Biochemistry

In fluorescence spectroscopy, a dimer of a fluorophore that is stable only in the excited state, e.g. of aromatics such as pyrene or 2,5-diphenyloxazole (PPO, used for scintillation counting).