The Battle of Jaxartes was a battle fought by Alexander the Great and his Macedonian army against the Scythians at the Syr Darya River, the supposed border river of Alexanders' new Empire in 329, BC.

As a result of the battle about 1200 Saccae were surrounded and killed, including their commander Satraces. Over 150 prisoners were taken and 1800 horses were captured. As far as the Macedonians and Greeks knew, no commander had ever been able to pin down and destroy a nomad army – including Darius the Great.

The northern frontier of Alexander's empire was never seriously threatened again.