The Battle of Uxian Defile was a battle between Alexander the Great and the Uxian tribe of the Persian Empire on the mountain range between the key Persian cities of Susa and Persepolis in December, 331 BC. Persepolis was the ancient capital of the Persian Empire and held a symbolic value among the native Persian population. They believed that if this city were to fall into enemy hands, then, in effect, the whole Persian Empire would fall into the hands of the enemy.

After some time fighting, the Uxians were entirely surrounded by the Macedonians, who put them to the sword.

The leftover Uxians almost immediately sued for peace. The agreed upon terms were as follows, each year they were to give to the Macedonians: 100 horses, 500 beeves, and 30,000 sheep.