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Home > Terms > English, UK (UE) > GABA shunt
GABA shunt
An alternative route from α-oxoglutarate to succinyl-CoA as part of the tricarboxylic acid cycle. Rather than going through the α-oxoglutarate dehydrogenase reaction, ¿-oxoglutarate condenses with NH3 to form α-iminoglutarate, then is reduced to glutamic acid, decarboxylated to γ-aminobutyrate (GABA), transaminated to succinic semialdehyde and oxidised to succinyl-CoA.
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- Part of Speech: noun
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- Category: Biochemistry; Molecular biology
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