Typhlosion, in appearance, becomes much different from its pre-evolutions; however, some resemblances remain. For instance, it is classified as a quadruped like Quilava, but it is capable of bipedal movement like Cyndaquil. The fiery vents on its back disappear, making way for a new ring of them around its neck and shoulders.

Typhlosion has a somewhat bearlike physique, with bulky thighs and a collar of fire around its neck. Typhlosion's ears are thinner compared to Quilava, and lack ear insides. Typhlosion's face, underside, arms, and legs are a shade of cream, and its back is dark blue. The fur of a Typhlosion is very coarse and highly flame-retardant, giving it an extreme resistance to heat and fire attacks. This may also be to keep it from injuring itself during battle when using attacks such as Flamethrower or Flame Wheel. On Typhlosion's rear is a spiky, coarse fringe of its back fur. Most of the time, when its mouth is open, it has a thick tongue.