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Desmosome

1) Desmosomes are intercellular anchoring junctions that anchor intermediate filaments at membrane-associated plaques in adjoining cells. Desmosomes assemble in response to cell-cell contact and raised levels of extracellular calcium. Sensitivity to calcium levels is lost as desmosomes mature.

2) A specialised local thickening of the plasma membrane of an epithelial cell that serves to anchor contiguous cells together.

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