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Home > Terms > English, UK (UE) > Flux-generating step
Flux-generating step
An enzymic reaction that limits the rate of subsequent steps in its metabolic pathway. In a steady state the flux of metabolites, expressed as mmol/min, is the same for all steps. The step is usually characterised by thermodynamic irreversibility, and the enzyme has a Km that is low compared with levels of its substrate in vivo, thus insulating itself and the pathway from variations in substrate levels.
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- Part of Speech: noun
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- Category: Biochemistry; Molecular biology
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