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Gusperimus
A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarisation of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukaemia cell lines.
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- Part of Speech: noun
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- Industry/Domain: Pharmaceutical
- Category: Cancer drugs
- Company: NCI
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