loss of heterozygosity (LOH)

loss of heterozygosity (LOH)

In a particular locus heterozygous for harmful mutant allele and a normal allele, removal or other mutational event within the framework of the normal allele renders the cell either hemizygous (one allele is harmful and one deleted allele) or a homozygous for deleterious allele.

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Part of Speech: noun
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Industry/Domain: Health care
Category: Genetic disorders
Company: National Library of Medicine
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