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Mapping

The creation of an outline of locations of genetic markers (genes or other polynucleotide sequences) within the structures of the chromosomes. The methodology determines the resolution of the map. Being dependent upon visual markers such as break points in the chromosomes, cytogenetic mapping is the least well resolved. Genetic linkage mapping is dependent upon linkage of markers, i.e. the frequency with which markers appear together within a population. Somatic cell hybrid mapping is dependent upon cell lines that contain a known whole human chromosome in a rodent cell or, in the case of radiation reduction hybrids, fragments of a known human chromosome interspersed within the chromosomes of a rodent cell.

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