A disease caused by tetanospasmin, a powerful protein toxin produced by Clostridium tetani. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. generalised tetanus, the most common form, is characterised by tetanic muscular contractions and hyperreflexia. localised tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalised form.