Molecular biology

Molecular biology

Industry: Biology

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Molecular biology

Fluorography

Biology; Biochemistry

A variant of autoradiography with improved sensitivity for detection of radioactivity of bands in slab gels. The weak β emission from 3 H, 14 C or 35 S excites a scintillant such as salicylate ...

Solvent-accessible surface

Biology; Biochemistry

A feature of a macromolecule defined by a molecular modelling technique, e.g. that of Connolly (a Connolly surface); the parts of the structure that are exposed to the solvent molecules are ...

The ease of access a drug or nutrient may have to its site of biological action; e.g. the ability of an antisense oligonucleotide designed to target a neuroreceptor to cross the blood-brain barrier, ...

Lectin

Biology; Biochemistry

A protein, other than one of the immunoglobulins, that binds to the non-reducing ends of a specific oligosaccharide, e.g. that of a glycoprotein or cell surface. Lectins are usually of plant origin, ...

DNA molecular decoy

Biology; Biochemistry

A synthetic polynucleotide with high affinity for a regulatory protein, such as a transciption factor, that can be used for research purposes, and potentially for therapy, to compete with the natural ...

Chromosome landing

Biology; Biochemistry

In positional cloning, an alternative to chromosome walking for finding a gene. Clones of genomic DNA are fragmented so as to include both the target gene and a closely linked marker and are screened ...

Linking clone

Biology; Biochemistry

A tool for the localization of restriction fragments within a physical map of the genome of an organism. A cloned fragment that contains very few of an already rare restriction site is used as a ...