Molecular biology

Molecular biology

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Molecular biology

Isothermal titration calorimetry

Biology; Biochemistry

ITC; A technique for measuring binding affinities (free energy of binding) of molecules in the low millimolar to nanomolar range. The heat absorbed or released during binding under equilibrium ...

The mechanism by which Ca 2+ signals a change in a myristoylated protein. In its non-liganded state, the acylated N-terminal amino group is buried in the protein's interior; upon binding to Ca 2+ , ...

Group transfer potential

Biology; Biochemistry

A quantitative measure of the strength of attachment of a moiety (the group) to the rest of the molecule; the difference in standard free energies between the group attached to the molecule and the ...

Adaptor hypothesis

Biology; Biochemistry

The proposal, made before the roles of mRNA and tRNA in protein synthesis were established, that a low-molecular-mass form of RNA provides the interface between each amino acid and the template. The ...

Pentacovalent intermediate

Biology; Biochemistry

An intermediate or transition state in phosphate reactions, in which an incoming oxygen atom displaces a leaving oxygen in a concerted reaction and forms a trigonal bipyramid in which the phosphorus ...

Pentose phosphate pathway

Biology; Biochemistry

The enzymic reactions that oxidatively convert glucose 6-phosphate into ribulose 5-phosphate and then to intermediates of the glycolytic pathway. The two oxidative reactions are the major source of ...

Michaelis-Menten kinetics

Biology; Biochemistry

The hyperbolic dependence of the rate of an enzymic reaction on substrate concentration that can be analysed mathematically according to a model that requires the reaction to proceed through a ...