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Colony hybridization
A technique for screening bacterial colonies for those that contain a desired polynucleotide sequence. A plate is exposed to a labelled oligonucleotide probe with a sequence complementary to part of the desired sequence which thus labels clones with that sequence. In a variant technique, plaque hybridization, phage vectors are screened for the desired polynucleotide sequence.
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- Part of Speech: noun
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- Industry/Domain: Biology
- Category: Biochemistry; Molecular biology
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