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Home > Terms > English, UK (UE) > Loss-of-function
Loss-of-function
Descriptive of a experimental biological model that is designed to be unable to express a particular trait; e.g. a cell line treated with an antisense oligodeoxynucleotide. This contrasts with a gain-of-function model, which has an additional or supplemented activity; e.g. a transgenic animal.
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- Part of Speech: adjective
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- Category: Biochemistry; Molecular biology
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