Molecular biology

Molecular biology

Contributors in Molecular biology

Molecular biology

An approach to design of polypeptide-like drugs, in which the C- or N-termini or side chains are linked to each other (end-to-end, side chain-to-side chain or end-to-side chain) in order to impose ...

Ala scan

Biology; Biochemistry

A series of structural variants of a peptide synthesised in order to evaluate the contribution of each residue to the peptide's binding. In each variant a different residue is replaced with an ...

Tailing

Biology; Biochemistry

A procedure that is part of one method for insertion of a polynucleotide into a circular plasmid. Addition of a homopolymer to the 3'-end of one unit and the complementary homopolymer to the 3'-end ...

Calcium-induced calcium release (CICR)

Biology; Biochemistry

A mechanism of cellular metabolic control: inositol 1,4,5-trisphosphate, generated in response to cell stimulation, causes a flow of Ca 2+ across the plasma membrane, which in turn leads to periodic ...

Fluorescence correlation spectroscopy

Biology; Biochemistry

The observation of fluctuations in the concentration of sparse fluorophores in a small observation area. Applications include estimation of transport coefficients as a fluorophore repopulates a ...

Enzyme

Biology; Biochemistry

One of a class of biological catalysts that is composed principally of a globular protein of one or more polypeptide chains. In some cases enzymes include covalently bound or tightly associated metal ...

Orphan receptor

Biology; Biochemistry

A membrane protein that has been discovered by cloning of its gene to be of the same family as known receptors, e.g. the G-protein-coupled receptors, but for which the activating ligand has not been ...