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Promoter

A sequence of dsDNA that regulates the binding and activity of RNA polymerase. The core promoter includes sequences within 40 nucleotides of a transcription start site; e.g. the initiator, TATA box, downstream promoter element, which separately or together direct synthesis by RNA polymerase II. Further upstream from the initiation site is the promoter-proximal region, which contains additional regulatory sequences. The core promoter and the promoter-proximal region are, collectively, the promoter.

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