Molecular biology

Molecular biology

Contributors in Molecular biology

Molecular biology

A protocol for site-directed mutation and construction of a vector containing the mutation. A pair of homologous complementary primers that contain the mutation are used separately with other primers ...

Koshland model

Biology; Biochemistry

A sequential model for the basis of co-operativity in multimeric binding proteins, originally presented as a description of oxygen binding to each of the haem groups of the haemoglobin tetramer. ...

KNF model

Biology; Biochemistry

A sequential model for the basis of co-operativity in multimeric binding proteins, originally presented as a description of oxygen binding to each of the haem groups of the haemoglobin tetramer. ...

Slippage

Biology; Biochemistry

A source of microsatellite polymorphism. During DNA replication, the polymerase periodically dissociates from the site of synthesis of the lagging strand. If this occurs in a microsatellite sequence, ...

Fourier transform infrared spectroscopy (FT-IR)

Biology; Biochemistry

The special case of the application to the infrared spectrum (10 -6 -10 -4 m) of interference optics. To avoid the disadvantage of dispersion/slit optics (the use of a prism or grating to separate ...

Funnel concept

Biology; Biochemistry

The new view of the protein folding problem in which the assortment of unfolded polypeptides are considered as an ensemble, the myriad of individual members of which achieve the native form by ...

Small molecule library

Biology; Biochemistry

A collection of related structures synthesised for screening for a desired property. The library may by synthesised by parallel, split or spatially addressable synthesis. Parallel synthesis is a ...