Molecular biology

Molecular biology

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Molecular biology

Mixed inhibition

Biology; Biochemistry

A form of enzyme inhibition in which the inhibitor binds to both the free enzyme and the enzyme-substrate complex, resulting in an increase in K m and a decrease in V max .

Multi-wavelength anomalous diffraction (MAD)

Biology; Biochemistry

For proteins that contain a heavy metal, or synthesised with selenomethionine in place of methionine, an approach to solving their X-ray crystallography structure that takes advantage of the ...

Optimal matching hydrophobicity (OMH)

A calculated value used to predict conformational similarities of proteins from their amino acid sequences. Numerical values for hydrophobicity, OMHs, are assigned to each amino acid residue to allow ...

High-energy bond

Biology; Biochemistry

A chemical bond whose hydrolysis results in the generation of ≧30kJ (7kcal) of energy or, if coupled to an energetically unfavourable reaction, can drive that reaction forward. Examples are found in ...

Ribozyme

Biology; Biochemistry

An RNA molecule that owing to peculiarities in its folding, is able to catalyse the interchange of some of its phosphodiester linkages to achieve intramolecular splicing. Examples of ribozyme groups ...

Allosteric regulation

Biology; Biochemistry

The modification of binding or catalytic properties of a protein by attachment of a regulator at a site distinct from the ligand- or substrate-binding site. Allostery typically results in sigmoidal ...

Area detector

Biology; Biochemistry

An 'electronic film'; a device for measurement of diffracted radiation, e.g. in X-ray crystallographic analysis; detector devices are densely arrayed over a screen and report to a computer the ...