Molecular biology

Molecular biology

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Molecular biology

Beta (β)-ribbon

Biology; Biochemistry

A DNA-recognition motif; a segment of antiparallel β-structure that can fit into the major groove of a double-stranded polynucleotide and bind to it due to very specific interactions between side ...

A technique used to define properties of a cellular, subcellular or tissue model, in which a variable or undesired constituent, e.g. membrane phospholipid, is removed (by a phospholipase) and then ...

Deletion map

Biology; Biochemistry

The linear arrangement of natural mutations along a chromosome or part of a chromosome. In the first phase many individuals are studied for the presence of cytogenetic markers; later phases use ...

Marker rescue

Biology; Biochemistry

A technique to localise the site of a mutation within a gene. A polynucleotide, the 'marker', from the known wild-type sequence is allowed to recombine with the mutant genome such that, if it ...

Mating-type switching

Biology; Biochemistry

A phenomenon in the behaviour of yeast and other organisms that rapidly change from the haploid to the diploid state. In yeast the two mating types are a and α; when two a or two α cells mate, the ...

Polyprotein

Biology; Biochemistry

A primary product of protein synthesis, a single polypeptide chain that will eventually be cleaved into several separately functional proteins; e.g. the precursor produced by retroviruses that gives ...

Isoschizomers

Biology; Biochemistry

A pair of restriction endonucleases that recognise the same palindromic sequence, although in some cases one member of a pair may differ from the other in its response to methylation of the ...