Biochemistry

Biochemistry

The scientific study of the chemistry of living matter.

Industry: Biology; Biotechnology

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Biochemistry

Monod-Wyman-Changeux (MWC) model

Biology; Biochemistry

A concerted model for the basis of co-operativity in multimeric binding proteins, originally presented as a description of oxygen binding to each of the haem groups of the haemoglobin tetramer. In ...

Node

Biology; Biochemistry

The point of contact of a strand of supercoiled DNA where it loops back on itself. A node, and the writhe of the DNA, may be positive or negative; it is positive if, when viewed so that the strand ...

Promoter

Biology; Biochemistry

A sequence of dsDNA that regulates the binding and activity of RNA polymerase. The core promoter includes sequences within 40 nucleotides of a transcription start site; e.g. the initiator, TATA box, ...

Anchored PCR

Biology; Biochemistry

A variation of the PCR technique, similar to ligation-mediated PCR, that is applied to double-stranded DNA fragments for which the sequence at only one end of the gene is known. The technique allows ...

Fluorescence in situ hybridization (FISH)

Biology; Biochemistry

A method for visualisation of a genetic marker on a chromosome by use of a fluorescent labelled polynucleotide probe that hybridises to and indicates the locus of a gene on a chromosome during ...

Double-sieve editing

Biology; Biochemistry

A proposed mechanism that accounts for the high selectivity of some enzymes, especially the amino acid activating enzymes. An initial screening sorts substrates by size - those too large cannot enter ...

Tier

Biology; Biochemistry

The cohort of chains of a branched-chain polysaccharide that all have the same relationship to the branch points. The outer tier of glycogen is all those glucosyl units that are attached in α1→4 ...