Biochemistry

Biochemistry

The scientific study of the chemistry of living matter.

Industry: Biology; Biotechnology

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Biochemistry

High-performance liquid chromatography (HPLC)

Biology; Biochemistry

A technique for rapid separation of solutes on a solid support, based on ion-exchange, gel permeation or partition principles; reverse-phase HPLC is when the stationary phase has a non-polar coat; ...

High-pressure liquid chromatography (HPLC)

Biology; Biochemistry

Multi-drug resistance (MDR)

Biology; Biochemistry

A phenomenon in which resistance that develops to one drug is manifested as resistance to many others, even those with very different structures; seen especially in chemotherapy. MDR is due to ...

Loss-of-function

Biology; Biochemistry

Descriptive of a experimental biological model that is designed to be unable to express a particular trait; e.g. a cell line treated with an antisense oligodeoxynucleotide. This contrasts with a ...

Gene conversion

Biology; Biochemistry

The replacement of an allele during crossing- over owing to mismatch repair of the heteroduplex intermediate; rather than being equally represented in daughter DNA strands, one allele is ...

Insulin

Biology; Biochemistry

A hormone secreted by the pancreas that binds to its specific cell surface receptor in tissues throughout the body. Insulin regulates multiple growth and metabolic actions of cells including glucose ...

Transcription factor

Biology; Biochemistry

A protein that binds to a specific DNA sequence and enhances or suppresses transcription of the target gene. One class is the basic helix-loop-helix proteins; upon associating with another molecule ...