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Immunology
Immunology is the study of the structuree and function of the immune system which is responsible for the protection from invading foreign macromolecules or organisms. It is a broad branch of biomedical science that covers the study of all aspects of the immune system in organisms. It deals with the physiological functioning of the immune system in both healthy states and immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo.
Industry: Biology
Add a new termContributors in Immunology
Immunology
CD4 T cells
Biology; Immunology
CD4 T cells are T cells that carry the co-receptor protein CD4. They recognise peptides derived from intravesicular sources, which are bound to MHC class II molecules, and differentiate into CD4 TH1 ...
Hybridomas
Biology; Immunology
Monoclonal antibodies are most commonly produced from hybridomas. These are hybrid cell lines formed by fusing a specific antibody-producing B lymphocyte with a myeloma cell that is selected for its ...
Variable region
Biology; Immunology
The variable region (V region) of an immunoglobulin or T-cell receptor is formed of the amino-terminal domains of its component polypeptide chains. These are called the variable domains (V domains) ...
J gene segments
Biology; Immunology
The J gene segments, or joining gene segments, are found some distance 5′ to the C genes in immunoglobulin and T-cell receptor loci. A V and in the case of IgH chains, TCRβ chains and TCRδ chains, a ...
Superantigens
Biology; Immunology
Superantigens are molecules that stimulate a subset of T cells by binding to MHC class II molecules and Vb domains of T-cell receptors, stimulating the activation of T cells expressing particular Vb ...
DNA-dependent kinase
Biology; Immunology
The genetic defect in scid mice, which cannot rearrange their T- or B-cell receptor genes and have a severe combined immunodeficiency phenotype, is in the enzyme DNA-dependent kinase. This enzyme is ...
Acute lymphoblastic leukaemia
Biology; Immunology
Acute lymphoblastic leukaemia is a highly aggressive, undifferentiated form of lymphoid malignancy derived from a progenitor cell that is thought to be able to give rise to both T and B lineages of ...
