Molecular biology

Molecular biology

Contributors in Molecular biology

Molecular biology

A method for comparison of different organs, or physiological or disease states by the genes that are uniquely expressed in them. The mRNAs of two types of cell to be compared, e.g. normal and cancer ...

Sequencing by hybridization

Biology; Biochemistry

A proposed approach to rapid sequencing of genomic DNA. The key tool for analysis is a superchip, a surface over which are attached at minute yet identifiable positions unlabelled oligonucleotide ...

Genetic footprinting

Biology; Biochemistry

An approach to the identification of the function of a large number of putative genes of a micro-organism, such as may have been uncovered by genome sequencing. A transposable element is inserted ...

P:O ratio

Biology; Biochemistry

The ratio of phosphate incorporated into ATP to oxygen atoms reduced to water; a measure of the efficiency of coupling of phosphorylation to oxidation. Based on the now-obsolete chemical coupling ...

Apoptosis

Biology; Biochemistry

A morphologically characterised process of programmed cell-death, initiated by various physiological or pathological causes (e.g. cell turnover, hormone-induced atrophy, cell-mediated immune ...

Cornish-Bowden plot

Biology; Biochemistry

A graphical method for determination of the type of enzyme inhibition and the dissociation constant for an enzyme-inhibitor complex (K i ) or for an enzyme-inhibitor-substrate complex (K i '). The ...

Glucose effect

Biology; Biochemistry

The repression of some bacterial enzymes by the presence of glucose in the growth medium. Depression of cyclic AMP levels due to the availability of glucose is mediated by inhibition of adenylate ...